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While the nephroprotective effects of SGLT2i were initially derived from secondary endpoints of CV outcome trials (CVOTs), direct confirmation came from dedicated kidney focused trials: CREDENCE (Perkovic et al NEJM 2019| NephJC Summary), DAPA-CKD (Heerspink et al NEJM 2020| NephJC Summary) and finally EMPAKIDNEY (Herrington et al NEJM 2023| NephJC Summary)

The medication targets your insulin levels, and as a result, you may end up feeling tired: If blood sugar drops too low, it can cause feelings of tiredness or lethargy, he says

Pancreatitis: There have been reports of pancreatitis (inflammation of the pancreas) associated with the use of Ozempic

Retatrutide adds glucagon-receptor agonism on top, which matters for reasons that the TRIUMPH-4 dataset has now made concrete