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Figure 2 UA induces macrophages to produce inflammatory cytokines MSU crystals induce macrophage production of inflammatory cytokines ( via the Syk and JNK kinase signaling pathways ( Tet2 knockout mice exhibited an increase in IL-1 secretion following MSU crystal administration

A diferencia de los medicamentos sintticos para dormir (benzodiazepinas, barbitricos) que inducen qumicamente un sueo no fisiolgico o sedacin, el DSIP funciona a travs de los mecanismos naturales de induccin del sueo del cerebro, las mismas vas neuronales que el cerebro activa al transicionar naturalmente al sueo

PMID 19773279