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The ratio ( K m / k cat ) tyramine /( K m / k cat ) dopamine , which expresses the preference of an enzyme for mono- or diphenols, was reduced 8.8-fold (0.45 for jr PPO1-wt versus 0.051 for Asn240Lys)

While preclinical studies, primarily in animal models, have yielded promising results, human clinical trial data is still limited when compared to FDA-approved therapies

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