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however, MLKL knockout mice remained susceptible to APAP-induced liver injury, indicating that necroptosis is not the primary mode of cell death in APAP-induced toxicity

Patients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those using diuretics concomitantly and the elderly

For example, glycolysis inhibitors can impair ATP production, preventing caspase-dependent apoptosis as metabolic dormancy [151]