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Radiotherapy inhibits tumor growth by generally inducing tumor cell apoptosis, necrosis, mitotic catastrophe, autophagy, or senescence through inflicting extensive DNA damage, including DNA-protein crosslinking, or transiently increasing the levels of cytotoxic reactive oxygen species (ROS) ( Irradiation-Induced GH Deficiency Subtle and frank neuroendocrine abnormalities occur following radiation damage to the hypothalamic-pituitary axis

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Uric acid shown to contribute to increased oxidative stress level independent of xanthine oxidoreductase activity in MedCity21 health examination registry