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Since the reduced precursors are hypothesized to synthesize NAD + through formation of NADH, administration of NRH and NMNH may offer an NAD + boosting avenue that is independent of both salvage and PreissHandler pathways, and is unaffected by the microbiome 58

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Gebka A, Serkies-Minuth E, Raczynska D

Despite their potential, polyphenols remain underutilized in functional foods and dietary supplements due to several physicochemical properties, including low epithelial permeability, poor solubility in gastrointestinal fluids, structural modifications during digestion, and limited oral bio-accessibility (128, 129)