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Despite the widespread use of serotonergic medications, benzodiazepines and cognitive behavioral therapy (CBT), therapeutic outcomes remain limited with less than 50% of patients reaching full remission and nearly one-third do not respond to conventional treatments (De Vries et al., 2016)

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-Sleep Inducing Peptide (DSIP) may act as a programming modulator at supra-operational level rather than as a transmitter at operational level[1]