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LAURIE SUND: Well, I think 42% of our population has obesity

In contrast, the hypothetical strategy, outlined in the ICH guidelines [3] (also known as the trial product estimand in some clinical trials [29]), provides information on the pharmacological effect of the tested therapy under the assumption that intercurrent events will not occur

These work by co-releasing with insulin to help slow down digestion and boost satiety

That trial enrolled 338 adults with obesity or overweight without type 2 diabetes, randomized across placebo and four retatrutide dose levels (1 mg, 4 mg, 8 mg, 12 mg weekly), and followed participants for 24 weeks