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It is worth mentioning that the genetically proxied effect of GLP-1RAs exhibited a causal effect on liver fibrosis in MASLD (OR: 3.70 10 4 , 95%CI: 5.29 10 6 0.03, P = 2.66 10 4 ) despite negative results in liver fibrosis (Supplementary Table 5)

Funding This work was funded by the Natural Science Fund Project of Science and Technology Department of Qinghai Province (2024ZJ979), the Youth Research Fund Projects of Qinghai University (2022QNY4, 2022QYY7), and the National Natural Science Foundation of China (32060088)

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