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A critic to the use of a murine model deficient for intestinal GCG products, would be that other gut hormones might compensate for the lack of a functional GCG gene in that tissue, hence explaining the normalized incretin effect

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For individuals with genuine clinical need such as those with obesity-related comorbidities or HIV-associated lipodystrophy referral to a specialist service is appropriate

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highest efficacy of any peptide class studied to date

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