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(2015) 10:e0121971

The Ensembl genome database identifies potential orthologs of genes, where it uses gene order conservation (GOC), which are based on the presence or absence of orthologous neighboring genes, and whole genome alignment (WGA) coverage, based on the alignment of putative orthologs, scores to determine whether a putative ortholog is high confidence or not

The substantial weight reduction observed with tirzepatide monotherapy (15-21% body weight in clinical trials) suggests that any perceived benefits likely reflect tirzepatide's pharmacological effects rather than synergistic action

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