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These studies have shown that ellagic acid can play an anti-RA role by targeting the MTA1/HDAC1-Nur77 signaling axis, inhibiting MTA1 to reduce HDAC1 levels and prevent Nur77 deacetylation, thereby enhancing Nur77 transcriptional activity to suppress synoviocyte hyperproliferation, inflammation, and oxidative stress while promoting cell apoptosis ( Geniposide (Figure 6C) is an iridoid glycoside derived from the dried mature fruits of Gardenia jasminoides Ellis and other medicinal plants, known for its anti-inflammatory, anti-angiogenesis, and immune-regulating activities

This confirms that d-carnitine should not be given to fish and also suggests that some of the findings of previous studies, which showed no differences between the inclusion of l-, d- and dl-carnitine in the diet ( Reference Du, Liu and Tian 24 , Reference Tian, Leng and Li 29 ) , were confounded by the presence of endogenous l-carnitine

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Bhatt DL, Szarek M, Pitt B, et al