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Retatrutide is an investigational triple receptor agonist (GLP-1, GIP, and glucagon) that remains unlicensed in the UK

Because of its role in metabolism, L-Carnitine is commonly incorporated into wellness, fitness, and weight management programs to support healthy energy levels and overall metabolic function

Nonclinical studies in rodents of clinically relevant doses of GLP-1 receptor agonists showed dose-related and treatment-duration-dependent increases in the incidence of thyroid C-cell tumors (adenomas and carcinomas)

Studies examining women with PCOS treated with liraglutide have shown improvements in menstrual regularity alongside metabolic benefits, suggesting that GLP-1-based therapies may positively influence reproductive function in this population through insulin sensitization and weight loss