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These could be signs of an infection or allergic reaction

Both immunoreactive gut glucagon and L-cells are present most abundantly in the distal small intestine and colon (31, 62)

2010;299(3):L425-433

Lipotoxic hepatocyte injury releases damage-associated molecular patterns (DAMPs) that activate Kupffer cells and recruit monocytes, which secrete cytokines (TNF-, IL-6, CCL2) to amplify inflammation and stimulate hepatic stellate cells (HSCs) via TGF-1 and PDGF (7678)