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Shaking the vial The most common and most damaging mistake is vigorous shaking to dissolve powder quickly

[42] Agarwal A, Sengupta P, Durairajanayagam D

Koohpeyma F, Siri M, Allahyari S, Mahmoodi M, Saki F, Dastghaib S

For example, in a 2021 study, as little as 100mg of dihydroberberine increased berberine blood levels better than 500mg of HCl, and another 2021 study (by Indena, the company that makes Berbevis) found that a phytosomal preparation resulted in a tenfold improvement in bioavailability compared with HCl.48 51 Based on these studies, you might conclude that the two bioenhanced forms are superior to berberine HCl