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Unfortunately, despite significant advances in anti-glycemic therapies, macrovascular complications are still the most common cause of death in T2D patients [5]

[DOI] [PMC free article] [PubMed] [Google Scholar] 116.Clevers H

Therefore, drugs that maintain mitochondrial homeostasis can inhibit ferroptosis in normal cells (such as cardiomyocytes and vascular endothelial cells), mitochondrial dysfunction is an important indicator of cardiovascular disease 45

The primary safety considerations involve thyroid function monitoring, awareness of potential medication interactions, and recognition of symptoms requiring medical attention