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Studies have shown that AST can improve diabetes-induced cognitive impairments and behavioral abnormalities by attenuating oxidative stress and neuroinflammation [41,42,106]

Clin Pharmacol Ther 73(5):435455 Weltman MD, Farrell GC, Hall P, Ingelman-Sundberg M, Liddle C (1998) Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis

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Puerarin has wide pharmacological properties, especially the activation of Sirtuin-1 (Zhou et al., 2014