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415,416,417 GLP-1RAs can exert their local effects by activating vagal dendritic terminals that innervate the gut
If nausea arises when GLP-1 RA plasma concentrations are at their peak, then continuous exposure to GLP-1 RAs may lead to tachyphylaxisa reduced response to the drug over timeresulting in fewer gastrointestinal symptoms after long-term use [20]
Your healthcare provider will review your complete medical history before prescribing
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