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In this regard, it is tempting to speculate that the accumulation of succinate (the CII substrate in the TCA cycle) in GSH-deficient FoB (Fig

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6 , 7 GLP-1 receptor agonists promote insulin secretion after meals, improve glycemic control and body weight (BW), and reduce the risk of cardiovascular complications for people with T2D and obesity.8, 9, 10 Moreover, the GLP-1 receptor agonist, semaglutide reduced the risk of a composite kidney end point in a dedicated kidney outcome trial