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The integration of glucagon-mediated energy expenditure with the appetite-suppressive and insulinotropic effects of GIP and GLP-1 agonism is hypothesized to explain the substantial weight loss and metabolic improvements observed in Phase 2 trials

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This has a broader population health benefit as greater access to these medicines will reduce the crippling strain obesity-related conditions have on NHS resources. In the UK, generic competition typically reduces prices paid by the NHS by as much as 80% to 90% after loss of exclusivity, according to the BGMA