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Hypoxia selectively upregulates cation channels and increases cytosolic [Ca(2+)] in pulmonary, but not coronary, arterial smooth muscle cells

In the ATTAIN-1 trial, adverse events led to treatment discontinuation in up to 10.3 percent of patients on the drug, compared to only 2.7 percent on placebo

clinical data is demonstrating their efficacy in treating fatty liver disease, cardiovascular conditions, and neurological disorders

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