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Here, we present a comprehensive study in -cell lines and primary islets that demonstrates that, following GLP-1RA stimulation, GLP-1R-positive endosomes associate with the endoplasmic reticulum (ER) membrane contact site (MCS) tether VAPB at ER-mitochondria MCSs (ERMCSs), where active GLP-1R engages with SPHKAP, an A-kinase anchoring protein (AKAP) previously linked to T2D and adiposity risk in genome-wide association studies (GWAS)

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KLOW's 46 hour half-life means late-morning administration (1011 AM) still produces meaningful beta-adrenergic receptor interaction, though peak fat oxidation will be slightly lower than optimal 7 AM timing

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