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Ondansetron is sometimes prescribed short-term during dose escalation

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In the pivotal STEP trials for semaglutide and SURMOUNT trials for tirzepatide, fatigue was systematically tracked and occurred more frequently in treatment groups than placebo groups

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Both oral semaglutide and injectable GLP-1 medications work through the same biological pathway, but they differ in delivery, convenience, and administration details: 1

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