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Second, the endpoint was an EEG spectral change , not a report of feeling sleepy
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For weight management, NICE guidance (CG189) emphasises lifestyle interventions as first-line treatment, with pharmacological options like semaglutide reserved for specific patient groups who meet eligibility criteria and have not achieved adequate weight loss through lifestyle measures alone
Semaglutide therapy was initiated at the start of the third postoperative year in these patients, administered as weekly subcutaneous injections (0.51.0 mg) over a 12-month period, followed by a gradual tapering and a subsequent observation period of at least one year
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