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Injection Site Rotation Best Practices for Long-Term Use Rotating your injection site each week across at least three to four different abdominal locations reduces your risk of developing local complications like lipohypertrophy, skin irritation, or injection-site nodules

Clinical trials including STEP 1 through STEP 5 demonstrated that semaglutide produces significant weight loss when combined with lifestyle changes

[5] Byetta (exenatide) [prescribing information]