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MRL/lpr mice A mouse strain with an Fs gene mutation (lpr) leading to defective lymphocyte apoptosis and lupus-like symptoms

Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons

Verdict: Limited evidence the absence of human trials reflects a combination of a cancelled unpublished safety study, specific FDA-documented safety concerns, and structural barriers that make large-scale human trials difficult to initiate and fund [4][10][1415]