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The mechanism involves changes in sex hormone binding globulin from rapid weight loss, reduced peripheral estrogen production from fat tissue reduction, and hypothalamic-pituitary-ovarian axis response to caloric restriction

Outliers were removed based on raw fluorescence data, if pipetting errors or air bubbles were identified after measurement, or if the final thiol concentration values fell outside one standard deviation from the mean

Gastroesophageal reflux disease (GERD) represents the chronic form of this condition, affecting approximately 20% of adults in developed countries

Inaba H, Martin W, Ardito M, De Groot AS, De Groot LJ