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Small peptide GLP-1R analogs including liraglutide, lixisenatide, and exendin-4 have all been demonstrated to cross the BBB upon peripheral administration [750,751], and HPLC analysis confirmed that most of the peripherally administered exendin-4 reaches the brain intact [751,752]
Another advantage of lomustine is that it can be administered orally, although we used intraperitoneal injection in our study to deliver an exact dose of lomustine to mice
doi:10.1002/14651858.CD010012.pub2
So, roll the vial gently on a flat surface (dont shake it), and wait at least two hours before injecting
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