Xue et al., 2019)
This is because, like many antidepressants, supplementary 5-HTP raises the amount of serotonin in the brain, so the combination could result in dangerous levels of the neurotransmitter.8 39 With that being said, lets take a look at how 5-HTPs ability to boost serotonin could be beneficial for those dealing with PMDD
However, there have been a few studies that have reported a link between chronic oral ingestion of high doses and the body's intestinal microbiota metabolism, leading to increased TMAO (a compound linked to cardiovascular risk) [7]
IL-1Ra knockout in mice led to accelerated IDD, represented by decreased proteoglycan, disrupted collagen structure, increased matrix-degrading enzymes, including MMP3, MMP7, and ADAMTS4, 144 and a higher histological grade of degeneration