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Consistent with this finding, single-nuclei RNA-sequencing (snRNA-seq) revealed that GIPR agonism and antagonism have opposing effects in the brain, with GIPR antagonism but not agonism mimicking the transcriptional responses of GLP-1R agonism in the dorsal vagal complex of the hindbrain (DVC), and with GIPR antagonism and GLP-1R agonism both modulating DVC gene programmes implicated in synapse formation and neuronal plasticity

It has a toning effect on the nervous system, allowing for winding down before bed and lowering psychological tension accumulated during the day

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This new research reported at AAIC 2024 suggests liraglutide may protect the brains of people with mild Alzheimers disease and reduce cognitive decline by as much as 18% after one year of treatment compared to placebo by slowing the shrinking of the parts of the brain that are vital for memory, learning, language and decision-making