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Nebert, D

Studies on animal models (mainly mice and rats) indicate the involvement of this peptide in the processes of extracellular matrix (ECM) remodeling and angiogenesis

However, the majority of current clinical studies are still based on isolated case reports or small cohorts, limiting the ability to systematically characterize the prevalence and disease-stage- and population-specific features of ferroptosis

Targeting specific redox modification As summarized above, redox signaling pathways are a regulatory mode of signal transduction that depends on redox modifications, controlling the biological functions of key proteins through reversible or irreversible redox modifications