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Serious and Potential Long-Term Risks More serious potential adverse effects have also been reported, including: Pancreatitis: Inflammation of the pancreas, which can be life-threatening

doi:10.1002/cpt.3567 Sattar N, Lee MMY, Kristensen SL, et al

Studies show that there is a J-shaped relationship (J-shaped relationship refers to a specific nonlinear association pattern where the plotted curve resembles the letter J. At low exposure levels, the risk decreases as the independent variable increases, but beyond a critical threshold, this trend reverses abruptly) between BMI and patient mortality

however, the exact enzymes involved are poorly understood