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As discussed above, rodent data are not completely applicable to human pathogenesis, and it has been noted that rodent islet histopathology is remarkably different from what has been observed in human samples (244)

218 Conceptually, however, it is not clear, if studies evaluating the response to an evoked visceral stimulus can be used to predict the response to spontaneous visceral pain, since the neurophysiological mechanisms are likely to be different