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Plasma levels remain elevated for 45 days after the final dose, though receptor-mediated effects diminish as concentration drops below the activation threshold

In addition to its outstanding glucose-lowering effect, DPP-4i have also shown non-metabolic functional activities, including anti-inflammatory effect and cardiovascular protection, particularly with regards to BP regulation

Market Expansion and Regulatory Evolution Regulatory bodies are becoming more aware that obesity is a long-term disease that needs medication treatment

Phase 3 Trial of Tirzepatide for Obesity (SURMOUNT-1). New England Journal of Medicine , 387(3), 205-216