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Thus, future large-scale comparative studies with longer follow-up are needed to accurately estimate the amputation risk associated with specific antidiabetic therapy across different categories of patients with T2DM

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These include: Redness, itching, pain, rashes, and sensitivity at the site of injection Dry mouth Nausea Headaches Lightheadedness Fever (that is transient, and goes away quickly) Some of these side effects are easily avoided or treated

It has been found that mutation in ZnT8 may contribute to dysregulation in insulin in the first passage through the liver and increase risk of type 2 diabetes mellitus development [136]