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Standard of Care) study for alogliptin (58, 62), the Savor-TIMI-53 study (Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes MellitusThrombolysis in Myocardial Infarction 53) for saxagliptin (60, 63), the TECOS study (Trial Evaluating Cardiovascular Outcomes With Sitagliptin) for sitagliptin (59, 64) and the CARMELINA study (Cardiovascular safety and Clinical Outcome with Linagliptin) for linagliptin (61, 65)

Weight loss results often become noticeable within one to two months , although timelines vary depending on individual metabolism, starting weight, and lifestyle factors

Evidence have shown that the process of metabolic reprogramming can be regulated by the underlying genetic factors that drive tumorigenesis