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The rapidly evolving landscape for CKD-protective therapies in type 2 diabetes currently includes sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RA), both of which demonstrate cardiorenal outcome benefits

Such symptoms may include vomiting, stomach pain, headache, dizziness, tiredness, irritation, insomnia, rash, heartburn, Increased liver enzymes, and nausea

This led to FDA black box warnings requiring screening for glucose intolerance before starting treatment and periodic monitoring during treatment, with recommendations against use in patients with poorly controlled diabetes