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These results suggest that epigenetic inactivation of GSTP1 plays an important role in the development of HCC and exposure to environmental carcinogens may be related to altered methylation of genes involved in hepatocarcinogenesis (Zhang et al., 2012)

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In a minority of patients, MS begins with a progressive course from onset where inflammation may be less prominent, though still plays a role in disability progression (Hughes et al., 2018)