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A study tracking patients on semaglutide for 12 months found mean vitamin B12 levels dropped from 567 to 494 micrograms per deciliter, a significant decline that happened quietly while patients focused on their shrinking waistlines

With the introduction of dual GLP-1/GIP-RA, ongoing studies could provide novel insights and new evidence on this topic

Truveta Research also found that patients taking tirzepatide experienced significantly larger reductions in body weight at specified timepoints: At 3 months, the mean percentage change in body weight was -5.9% for those taking tirzepatide versus -3.6% for those taking semaglutide

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