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Overweight and obesity are growing health challenges affecting many people globally

Based on the shared pathogenesis, including estrogen regulation and inflammation, potential therapeutic drug targets (cholecystokinin B receptor and phosphodiesterase 4B) were identified, providing evidence of shared disease etiology and implicating clinical diagnostic and treatment decisions for both diseases (131)

Meanwhile, single-cell RNA sequencing (scRNA-seq) has revealed that stem-like cell populations with elevated OXPHOS activity contribute to drug resistance and metastatic potential, providing direct evidence for the cellular basis of metabolic heterogeneity in CRC [166, 167]

Sixteen state Medicaid programs reported covering GLP-1s (glucagon-like peptide-1s) for obesity treatment as of October 1, 2025, and some states reported plans to restrict coverage in the future