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Besides, D2R modulates astroglial and microglial activity via decreasing the microglial AT1/AT2 ratio, thus inhibiting AT1/NADPH-oxidase/superoxide axis, based on AT1-D2R heteromers ( D3R Genetic deficiency of D3R, attenuated neuroinflammation and subsequent neurodegeneration on a murine model of PD induced by acute intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (121), related to the limited basal production of Fizz1 (122), confirmed by a study that compared with the control group, PD patients have increased Th1 cells and Th17 cells but decreased Tregs (123)