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In contrast, ACTH is the only endogenous peptide that agonizes MC2R (29)

Difficulty Passing Gas: If you are unable to pass gas along with severe constipation and abdominal pain, it could suggest a complete bowel obstruction

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In addition, mitochondria lack more advanced repair pathways, such as nucleotide excision repair and homologous recombination, which makes mtDNA particularly susceptible to the accumulation of mutations [35], which leads to a higher rate of damaged mtDNA in mitochondria and further aggravates oocyte damage