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And he goes, yeah, I don't know whether or not this calcification thing is real

The preclinical foundation is strong, particularly for BPC-157 and thymosin beta-4, but the gap between animal evidence and clinical application can only be bridged through rigorous controlled studies in human fracture patients

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The FDA added it to injectable semaglutide in January 2025, and it climbs the dose axis like everything else. Burning or tingling skin tracks the dose, not the weight lost, and an active-comparator study put the risk about twice that of another weight-loss drug. The mechanism is unsettled: the tempting "it is the drugs signaling arm" story is ruled out, because the strongest GLP-1 signaler in the class carries no such signal