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In recent years, research has attempted to show the power of glutamine modulation as a complementary approach in cancer therapy [11,15,16]
These findings raise important questions about why direct GLP-1R agonism is effective while DPP-4 inhibition is not, highlighting the need to better understand the underlying mechanisms involved in this intervention, and how this knowledge can be leveraged to refine and optimize therapeutic approaches for AUD
In this article, the authors showed that uPAR is expressed in senescence cells, both in in vivo and in vitro models (liver fibrosis, pancreatic intraepithelial neoplasia, senescent melanocytes, or lung cancer) correlated to a lack of expression in healthy tissue, except for the bronchial epithelium and a subset of immune cells in which a weak expression of uPAR was detected