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Systemic absorption from creams is low but because high oral vitamin A is a known teratogen and topical safety data are limited, most clinicians recommend stopping retinoids when pregnant or trying to conceive

However, if a recommendation is listed, it is critically important

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Isotretinoin (Accutane ) may cause your acne to flare in the first month or two of treatment, sometimes with severe flaring (pseudo acne fulminans).- This is usually minimized by starting out at a low dose of Accutane for the first month