Lipid peroxidation-driven chondrocyte ferroptosis in OA Ferroptosis was first reported by Dixon et al
In humans, dietary l-carnitine is converted into the atherosclerosis- and thrombosis-promoting metabolite TMAO via 2 sequential gut microbiotadependent transformations: (a) initial rapid generation of the atherogenic intermediate BB, followed by (b) transformation into TMA via low-abundance microbiota in omnivores, and to a markedly lower extent, in vegans/vegetarians
Maternal hypothyroidism has been associated with increased risk for preeclampsia, miscarriage, stillbirth, preterm birth, and low-birth-weight infants (reviewed in 12)
Preclinical work and early clinical trials indicate preferential intratumoral accumulation, sustained inhibition of topoisomerase I and hypoxia-inducible factor 1 alpha (HIF-1), and downregulation of HIF-1-related markers such as carbonic anhydrase IX in human tumor biopsies [90,91,92]