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Clinical practice suggests that antithyroid drugs combined with -adrenergic receptor antagonists can be used as effective drugs for the treatment of mental disorders and psychiatric symptoms caused by hyperthyroidism, as the excessive activation of the adrenal system induced by hyperthyroidism can lead to somatic symptoms ( Additionally, psychosomatic synchronization therapy is considered to be suitable for GD patients with psychiatric symptoms (185), as research has shown that the combination of antithyroid, antipsychotic drugs and psychotherapy contribute to the prognosis of the disease (186)

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In a recent study, it showed that there were no significant differences in the frequency of gastrointestinal side effects for both tirzepatide and semaglutide

Thermogenic markers in the BAT (e.g., Ucp1 , Dio2 , and Ppargc1a ) were less expressed in GCGKO mice under cold exposure, while UCP1 was also reduced in ambient conditions