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* Correspondence: Giuseppe Cappellano, [email protected] These authors have contributed equally to this work and share first authorship These authors have contributed equally to this work and share senior authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

541 The BBB controls the entry of circulating substances and cells into the brain, maintaining the stability of normal brain function and serving as the primary barrier for iron entry

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Some research protocols account for this by using comparatively lower dosing ranges in female study cohorts, reflecting a generally increased sensitivity to IGF-1 receptor activation a pattern also documented in broader growth hormone axis research, not unique to IGF-1 LR3 specifically