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These alterations in the tumor ECM induce an increase in its stiffness, typically evaluated using techniques that either require direct contact with the sample (e.g., atomic force microscopy), or measure the tumor mechanical properties in a contact-free manner (e.g., shear wave elastography, magnetic resonance elastography) (Table 3)

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However: It can cause water retention, increased appetite, and insulin sensitivity changes in some users

63, 64, 65 These common neoplasms classically develop in old gray horses and are also described in nonequine animal models such as those induced via cutaneous application of topical carcinogens