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A control group of about 300 patients took SGLT-2 inhibitors (e.g., canagliflozin, dapagliflozin, empagliflozin), drugs that are comparable to GLP-1 receptor agonists at lowering blood glucose levels

The broader picture is that the next generation of obesity treatments involves multi-target approaches, whether through single molecules activating multiple receptors (tirzepatide, retatrutide, survodutide, mazdutide) or through combination therapies pairing separate compounds (CagriSema)

Follow-up Repeat metabolic markers after 8-12 weeks or sooner if appetite, hydration, vomiting, or glucose symptoms change

Its the best demonstration so far of two-way communication between ourselves and the bacteria in out gut: what we eat affects the bacteria, and what they do with what we eat can influence health. Based on the Nature Medicine study, Id be concerned about taking L-carnitine supplements, Dr